6-letter words with Y as the 2nd letter and S as the 4th letter

The pattern is unusually tight: only 19 tournament-list entries fit, and none ranks among the top 25,000 English words by frequency. GYPSUM, MYOSIN, and HYSSOP are recognizable examples, but this is mainly a word-game lookup rather than a vocabulary list. The repeated -ses and -ases endings help explain why 15 candidates finish with S.

6-letter words with Y as the 2nd letter and S as the 4th letter

• Exactly 19 six-letter entries meet the Y-at-second, S-at-fourth pattern.
• Collins contains 19; NWL2023 has 16, while ENABLE has 15.
• Fifteen candidates end in S; only four end in L, M, N, or P.
• M begins five entries, more than any other first letter.
• None falls within the top 25,000 English words by frequency.

Which high-scoring words fit the pattern?

At 14 points each, GYPSUM and HYSSOP top the scoring table; the average is 10.7. Both are strong rack candidates when a premium square can multiply a high-value letter, but their unusual spellings make them poor guesses unless your crossings support them.

MYOSIN, BYSSUS, BYSSAL, CYESIS, MYOSIS, MYASES, MYASIS, and CYESES each score 11. That cluster gives you alternatives if either leader is blocked. MYOSIN and MYOSIS differ by one vowel, so check crossing letters before committing to one spelling.

Starting-letter counts offer another shortcut: five entries begin with M, while B, C, L, N, and P contribute two apiece. E and G contribute one each. If your first tile is fixed, try M before scanning the smaller pairs; this set is too sparse for a broad alphabetical sweep.

How should you filter these patterned words?

Start with the last letter if your rack or crossing clue supplies one: 15 of the 19 matches end in S. The four exceptions split across L, M, N, and P, represented by BYSSAL, GYPSUM, MYOSIN, and HYSSOP.

That distribution makes a final S a strong first filter, not a guarantee. Dictionary coverage differs: Collins has all 19 matches, compared with 16 in NWL2023 and 15 in ENABLE. Not every match appears in all three lists, so check the word list your game uses before committing.

A nearby clue with O second and S fourth has 232 matches, making the Y version especially narrow. For 6-letter words with Y as the 2nd letter and S as the 4th letter, the ending is a quick filter; compare Y-second patterns with R or T fourth for 19 or 24 matches.