6-letter words with I as the 2nd letter and S as the 4th letter

The fixed pattern is _I_S__, and all 83 matches appear in at least one tournament dictionary. Familiar entries such as MISSED, TISSUE and DIESEL sit beside less everyday options like VIZSLA and KIRSCH. The strongest play depends on your game's word list and on placing a high-value letter on a premium square.

6-letter words with I second and S fourth

• 83 six-letter entries match I in position two and S in position four.
• Collins includes 82; NWL2023 includes 60; ENABLE includes 56, with overlap among the lists.
• Only 14 entries are classed as common; MISSED and TISSUE are familiar starting points.
• VIZSLA leads the scoring examples at 18 points, with JIGSAW at 17.

Which letters begin and end these words?

M is the leading first letter: 18 words begin there, more than twice K's 8. MISSED, MISSES and MISSUS show how that opening pairs with several endings; KISSES gives the same repeated-S feel from K. The initials thin out after that: D contributes 7, while B and P contribute 6 each.

At the final position, S dominates with 27 matches. D and Y tie at 8 apiece; MISSED and BIASED end in D, while MIMSEY ends in Y. Keep the last tile open until you confirm the pattern rather than assuming a familiar word ending.

The same I/S position pattern expands to 172 seven-letter matches, but contracts to 25 at five letters. This six-letter set offers more choices than the five-letter version, yet far fewer than the seven-letter one. For another six-letter pattern, H in position two and S in position four has 51 matches.

Which matches have the strongest tile scores?

The gap between VIZSLA and JIGSAW is only one point, so board placement can outweigh choosing the nominal leader.

For 6-letter words with I second and S fourth, the common-word count is a real limitation: only 14 matches are classed as common. Collins has 82 matches, compared with 60 in NWL2023 and 56 in ENABLE, and definitions exist for only 66. Check your game's word list before playing an unfamiliar entry.