6-letter words with Y as the 2nd letter and E as the 4th letter

With Y fixed in slot two and E in slot four, the remaining letters create a sharply restricted set. Only one match, myself, ranks among the top 25,000 English words by frequency, while lyceum, wyvern, xylene, and pyrene show how odd the rest get. Treat this as a pattern-solving pool, not a set of everyday guesses.

6-letter words with Y second and E fourth at a glance

• The tournament-dictionary total is 23: Collins has 23, NWL2023 has 19, and ENABLE has 18.
• Myself is the only match in the top 25,000 English words by frequency.
• Eleven matches end in S; five end in E.
• Zydeco leads the Scrabble scores at 21 points.

Which endings appear most often?

S is the clear ending to test first: 11 of the 23 matches finish with it, more than twice the five that end in E. Two finish in N; A, F, K, M, and O each occur once. If your final tile is unknown, S gives you the strongest starting guess.

The contrast with other patterns is striking. With E still in slot four, changing the second letter from Y to A raises the count from 23 to 328. Keeping Y but putting N in slot four also yields 23 matches, so E is not uniquely restrictive among Y patterns.

Where do the points come from, and which words count?

Zydeco scores 21 Scrabble points, ahead of xylems at 18, rypeck at 17, and xylene at 16. Its Z and C make it the standout when the board offers a premium square; the average score across this group is 13.

For 6-letter words with Y second and E fourth, dictionary coverage matters more than familiarity. Collins lists 23 matches, compared with 19 in NWL2023 and 18 in ENABLE. Those totals overlap, so check your game's word list before playing; many matches are uncommon outside word games.