6-letter words with O as the 2nd letter and S as the 4th letter

Fix O in slot two and S in slot four, then use your other known letters to narrow the choices. Familiar matches include HOUSES, HORSES, LOSSES, and POISON, but the pattern also reaches less everyday words such as ZOYSIA. Just 19 matches rank as common by frequency, so expect plenty of specialist vocabulary among the possibilities.

6-letter words with O second and S fourth at a glance

• 232 six-letter entries match the O-in-second, S-in-fourth pattern.
• Only 19 matches rank as common by English word frequency.
• Collins has 228 matches, NWL2023 has 150, and ENABLE has 138; the dictionary lists overlap.
• S is the most frequent final letter, appearing at the end of 75 matches.

How many matches end in S?

75 matches finish in S, the largest final-letter group. D appears at the end of 34 words, R of 31, and E of 20. A final S is a strong clue, not a requirement: HOUSED, POISED, and WORSEN all fit the fixed letter positions without ending in S.

The remaining letters make the pattern varied. HOUSES, HORSES, LOSSES, and BOSSES have a familiar repeated-S shape; POISON, FOSSIL, GOSSIP, and NOISES fill the same slots differently. For comparison, 427 six-letter words have O second and I fourth, while 282 have O second and E fourth.

Which matches offer the strongest scoring angle?

ZOYSIA leads the scoring examples at 18 points, followed by ZOISMS at 17. MOKSHA and ZOISTS each score 15, while BOLSHY, BOWSEY, and BOWSAW reach 14. Those less familiar words can beat everyday choices on tile value, but they only pay off if your game accepts them.

For a more recognizable match, start with HOUSES, POISON, or FOSSIL, then check the crossing letters. The 6-letter words with O as the 2nd letter and S as the 4th letter are not all equally familiar, and only 19 are common by frequency. Check your game's word list before building a play around an obscure scorer.