6-letter words with O as the 2nd letter and Y as the 4th letter

That fixed pattern leaves a compact, unusually obscure set: none of the 17 entries falls within the top 25,000 English words by frequency. CORYZA leads the Scrabble scores at 20, while POLYPS and BOWYER are more recognizable anchors. The starting letters narrow the search: C begins five entries and P begins four.

How many 6-letter words have O second and Y fourth?

• There are 17 matches in Collins; ENABLE includes 11 and NWL2023 includes 12.
• Five words begin with C, and four begin with P, making C the most common first letter.
• Five end in E and four end in S; those endings cover nine of the 17 words.
• CORYZA scores 20 points, the top score; CORYMB follows at 15.
• None ranks among the top 25,000 English words by frequency, so expect unfamiliar vocabulary.

Which words score highest?

CORYZA is the standout at 20 points, with CORYMB next at 15. BOWYER, MORYAH, and COVYNE each score 14; POLYPS, DOHYOS, POLYPI, POLYPE, and COTYPE each score 13. Premium squares change the final board total, but the tile values make CORYZA the clear base-score leader.

Don't confuse a high score with an easy play: the pattern has zero common entries under the frequency cutoff. CORYZA and CORYMB are less familiar than POLYPS, and your rack and board still decide whether any option fits.

How can you narrow the pattern?

For 6-letter words with O second and Y fourth, slot positions are the fastest filter: keep O in place, mark Y in slot four, then sort by the known first or last tile. C and P account for nine openings together, while E and S account for nine endings. That split cuts the 17 candidates quickly.

The examples also form visible clusters: POLYPS, POLYPI, and POLYPE share POLYP; CORYZA and CORYMB share CORY. These anchors make scanning quicker, but every candidate still has to preserve O as letter two and Y as letter four.

Dictionary coverage is uneven: Collins lists all 17, compared with 11 in ENABLE and 12 in NWL2023. A Collins-valid option is not automatically accepted in an ENABLE or NWL2023 game, so check your game's word list before committing to an unfamiliar pattern.