6-letter words with C as the 2nd letter and E as the 4th letter

The fixed pattern is _C_E__, so the second tile must be C and the fourth E. ACCESS, ACCEPT, SCREEN, SCHEME, and SCREAM are recognizable anchors; eight of the 34 entries rank among the top 25,000 English words by frequency. The pattern is narrow beside the 328 matches for A in the second slot with E still fourth.

Counts and standout words at a glance

• Collins includes 33 of the 34 matches; NWL2023 includes 26 and ENABLE includes 25.
• Fourteen begin with S, while eight begin with A and seven begin with O.
• Eleven end in S; seven end in T, making those the leading final letters.
• ECZEMA scores 19 points, the highest standard tile total among these examples.

6-letter words with C as the 2nd letter and E as the 4th letter

ACCESS and ACCEPT start with A; SCREEN, SCHEME, SCREAM, and SCREWS start with S. That S-heavy opening is striking: S accounts for 14 matches, nearly twice the eight beginning with A. If the first letter is unknown, test S before less common openings.

The ending gives another useful filter. Eleven words finish in S and seven in T, while E closes five. SCREEN ends in N, SCHEME in E, and SCREAM in M, so checking the final tile can quickly separate familiar candidates.

Only eight matches are common by the site’s frequency measure. That makes ACCESS, ACCEPT, SCREEN, and SCHEME stronger everyday guesses than obscure options such as SCREED or SCREES.

Which matches score highest, and what should you check?

ECZEMA leads at 19 points, well ahead of SCREWY and OCHERY at 14 each. SCHEME, SCHEMA, and SCHELM each score 13. The uncommon X in ECZEMA drives its score, so do not overlook it when a rack or board position supports the pattern.

These 6-letter words with C as the 2nd letter and E as the 4th letter are a constrained match, not a list of everyday vocabulary: 27 entries have definitions, but only eight meet the common-word cutoff. Check your game’s word list before relying on a rare candidate; availability differs across Collins, NWL2023, and ENABLE.