7-letter words with Y as the 2nd letter and O as the 4th letter

75 7-letter words with Y as 2nd and O as 4th fit this pattern, from SYNONYM to HYPOXIC.

75 wordsTop pick SYNONYMHighest score HYPOXIC 24

1 of 75 are everyday words (1%). Mostly rare words: great for Scrabble, tough for daily puzzles.

With Y in 2nd place, O is the most common 4th letter (75 words). The bar under each letter shows the size of its list.

  • Length
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Best words to play first 75 · most-used first

  • SYNONYM15
  • HYPOXIA22
  • CYBORGS15
  • HYPOXIC24
  • TYCOONS12
  • BYGONES13
  • CYTOSOL12
  • ZYGOTES20
  • PYLORIC14
  • SYNODIC13
  • SYNODAL11
  • ZYGOTIC22
  • MYCOSIS14
  • PYLORUS12
  • ZYMOGEN22
  • MYCOTIC16
  • TYLOSIN10
  • ZYMOSAN21
  • PYROGEN13
  • MYCOSES14
  • BYWORDS16
  • BYROADS13
  • PYROSIS12
  • MYLODON13
  • ZYMOSIS21
  • TYRONES10
  • SYCOSIS12
  • PYROPES14
  • SYCONIA12
  • MYXOMAS21
  • AYWORDS14
  • BYCOKET18
  • BYROOMS14
  • BYWONER15
  • BYWORKS19
  • CYTODES13
  • DYNODES12
  • DYSODIL12
  • DYVOURS14
  • DYVOURY17
  • GYROCAR13
  • GYRONIC13
  • GYRONNY14
  • HYLOIST13
  • HYPOGEA16
  • HYPOIDS16
  • HYPOING16
  • HYPONEA15

Showing the top 48 of 75 words. See every valid word

All valid words 75

A to Z. Includes rare and Collins-only words. Linked tiles open the word's meaning, score and rhymes.

  • AYWORDS14
  • BYCOKET18
  • BYGONES13
  • BYROADS13
  • BYROOMS14
  • BYWONER15
  • BYWORDS16
  • BYWORKS19
  • CYBORGS15
  • CYTODES13
  • CYTOSOL12
  • DYNODES12
  • DYSODIL12
  • DYVOURS14
  • DYVOURY17
  • GYROCAR13
  • GYRONIC13
  • GYRONNY14
  • HYLOIST13
  • HYPOGEA16
  • HYPOIDS16
  • HYPOING16
  • HYPONEA15
  • HYPONYM20
  • HYPOXIA22
  • HYPOXIC24
  • LYCOPOD15
  • LYSOGEN11
  • MYCOSES14
  • MYCOSIS14
  • MYCOTIC16
  • MYLODON13
  • MYSOSTS12
  • MYXOMAS21
  • NYLONED11
  • PYLORIC14
  • PYLORUS12
  • PYROGEN13
  • PYROLAS12
  • PYRONES12
  • PYROPES14
  • PYROPUS14
  • PYROSES12
  • PYROSIS12
  • SYBOTIC14
  • SYCONIA12
  • SYCOSES12
  • SYCOSIS12
  • SYNODAL11
  • SYNODIC13
  • SYNONYM15
  • SYNOVIA13
  • TYCOONS12
  • TYLOPOD13
  • TYLOSES10
  • TYLOSIN10
  • TYLOSIS10
  • TYLOTES10
  • TYRONES10
  • TYRONIC12
  • XYLOGEN18
  • XYLOMAS19
  • XYLONIC19
  • XYLOSES17
  • ZYGOMAS22
  • ZYGOSES20
  • ZYGOSIS20
  • ZYGOTES20
  • ZYGOTIC22
  • ZYMOGEN22
  • ZYMOMES23
  • ZYMOSAN21
  • ZYMOSES21
  • ZYMOSIS21
  • ZYMOTIC23
Letters by positionIn 51% of these words the 7th letter is S.
1st letter
  1. Z15%
  2. P12%
  3. S11%
3rd letter
  1. L19%
  2. R19%
  3. C12%
5th letter
  1. S23%
  2. N17%
  3. R8%
6th letter
  1. E33%
  2. I28%
  3. A9%
7th letter
  1. S51%
  2. C13%
  3. N9%

Highest-scoring words

Scrabble and Words With Friends points, before board bonuses
Score spreadMost of these words score 12 in Scrabble; HYPOXIC tops the list with 24. Scores before board bonuses.
  1. 1010 points: 5 words
  2. 11 points: 3 words
  3. 1212 points: 14 words
  4. 13 points: 11 words
  5. 1414 points: 10 words
  6. 15 points: 5 words
  7. 1616 points: 5 words
  8. 17 points: 2 words
  9. 1818 points: 2 words
  10. 19 points: 3 words
  11. 2020 points: 4 words
  12. 21 points: 4 words
  13. 2222 points: 4 words
  14. 23 points: 2 words
  15. 2424 points: 1 words
WordScrabbleWords With FriendsDictionaries
HYPOXIC2424All three
ZYMOTIC2324All three
ZYMOMES2324Collins only
HYPOXIA2221All three
ZYGOTIC2223All three
ZYMOGEN2224All three
ZYGOMAS2223All three
ZYMOSAN2122All three
ZYMOSIS2121All three
MYXOMAS2122All three
ZYMOSES2121All three
ZYGOTES2020All three

Only one of the 75 matches falls in the common-word band, making this a specialist pattern rather than an everyday vocabulary set. Familiar entries such as SYNONYM and TYCOONS share space with technical terms including HYPOXIA, ZYMOGEN, and PYROGEN. The letter positions are fixed, but the remaining slots produce words with very different familiarity and rack value.

At a glance: a rare letter pattern

  • Exactly 75 tournament-dictionary entries match Y in position 2 and O in position 4.
  • Only 1 match is common by our frequency threshold.
  • Z starts the most entries, with 11; P is next with 9.
  • S is the most frequent final letter: 38 matches end in S.
  • Collins covers 73 entries, versus 52 in NWL2023 and 48 in ENABLE.

Which 7-letter words have Y second and O fourth?

The 75 matches include SYNONYM, HYPOXIA, CYBORGS, HYPOXIC, TYCOONS, and BYGONES. Those examples show how widely the remaining letters can vary while Y and O stay locked into their positions.

Z leads the first-letter tally with 11 words; P follows with 9, while H, S, and T each begin 8. A Z at the front therefore gives you the largest starting-letter group, though the pattern also has several options with more familiar initial letters.

The endings are just as uneven: 38 words finish in S, while C is next with 10. If your rack or grid points toward a plural-looking ending, check S before testing less common final letters.

7-letter words with Y as 2nd and O as 4th: play notes

HYPOXIC is the top scorer at 24 points. ZYMOTIC and ZYMOMES score 23, while HYPOXIA, ZYGOTIC, ZYMOGEN, and ZYGOMAS each score 22. X and Z do much of the scoring work, so a technical-looking word can outscore a more familiar one.

For a rack with seven tiles, fitting the whole word also matters: Scrabble awards a bingo bonus for using all seven tiles. Keep the fixed Y and O in mind as anchors, then look for high-value letters such as X or Z in the remaining spaces.

Dictionary coverage is a real limitation for this pattern: Collins includes 73 matches, but NWL2023 includes 52 and ENABLE includes 48. The counts do not guarantee that a particular word is accepted in your game, so check its word list before committing a specialist entry.

Questions people ask

Are any 7-letter words with Y second and O fourth common?
Only one of the 75 matches falls in the common-word band. SYNONYM is a recognizable example, but many other entries are technical or uncommon. Treat familiarity as a clue, not a guarantee: the pattern contains plenty of valid tournament words that may not come to mind in ordinary conversation.
What is the highest-scoring word in this pattern?
HYPOXIC scores 24 points, the highest score among these matches. ZYMOTIC and ZYMOMES follow at 23 points, with HYPOXIA, ZYGOTIC, ZYMOGEN, and ZYGOMAS at 22. The X and Z tiles explain why several less familiar words lead the scoring group.
Are all 75 words accepted in every word game?
No; dictionary coverage differs across the tournament lists. Collins includes 73 matches, NWL2023 includes 52, and ENABLE includes 48. A word's presence in one list does not establish that your game accepts it, so confirm the active dictionary before playing an unfamiliar entry.

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