7-letter words with P as the 2nd letter and O as the 4th letter

The fixed letters leave a compact group: only five entries fall within the top 25,000 English words by frequency, while 59 have a definition. OPPOSED, APPOINT, and OPPOSES are the clearest everyday anchors; SPOONER and APROTIC are less familiar. Dictionary coverage varies: Collins has 65 matches, NWL2023 has 52, and ENABLE has 47, so confirm your game’s lexicon before playing.

At a glance: starts, endings, and scores

• The P-second, O-fourth pattern matches 66 seven-letter entries across tournament dictionaries.
• U leads the first-letter count with 23, ahead of S at 18 and A at 17.
• S is the strongest ending: 25 words end in S, versus 13 ending in D.
• UPLOCKS leads the score list at 15; SPOOKED, SPLOTCH, APHOTIC, APHONIC, and SPLODGY each score 14.
• Only 5 entries meet the common-word frequency cutoff.

How many 7-letter words have P second and O fourth?

Exactly 66 seven-letter words fit this pattern in at least one tournament dictionary. The starting letters divide sharply: 23 begin U, 18 begin S, and 17 begin A. U is the largest opening group, even though familiar examples such as OPPOSED, APPOINT, and OPPOSES often catch the eye first.

The fixed positions still allow several recognizable word families. OPPOSED and OPPOSES share a base, while SPOOKED, SPOONED, and SPOOLED show how S-P-O sequences fit the same slots. At the other end, 25 entries finish in S and 13 finish in D, so a known final tile narrows the search quickly.

Narrowing down the P-second, O-fourth words

UPLOCKS tops the score list at 15, just ahead of five words scoring 14: SPOOKED, SPLOTCH, APHOTIC, APHONIC, and SPLODGY. That makes this pattern more promising for score hunting than its small common-word group suggests; most of its 66 matches are not everyday vocabulary. Prioritize a premium square only when the board keeps that letter safe.

Keep P and O anchored, then sort possibilities by the last letter you know. The 25 S-ending words include OPPOSES and UPHOLDS; OPPOSED and SPOOKED illustrate the D-ending group of 13. For another clue, compare this pattern with seven-letter words that keep P second but change the fourth letter.