6-letter words with U as the 2nd letter and O as the 4th letter

The pattern is _U_O__, with U fixed in position two and O in position four. RUMORS and TUMORS illustrate the strong S ending, while AURORA offers a familiar example without that final letter. Just 11 matches rank among the most frequent English words, leaving much of this set to specialist vocabulary.

The pattern at a glance

• 81 six-letter words fit _U_O__, with U second and O fourth.
• R starts 12 matches, more than any other first letter.
• S finishes 33 words; A, E, and T finish 7 each.
• Only 11 matches rank among the most frequent English words.

How many match U second and O fourth?

The U-O position pair produces 81 matches in tournament dictionaries. Change U to E and the same positions yield 254 words, a much broader search. RUMORS, HUMOUR, and AURORA are familiar anchors; many of the other entries are less likely to appear in everyday writing.

A final S is the standout clue: 33 words end that way, while A, E, and T each occur at the end of 7. RUMORS and TUMORS look like straightforward plural forms, but the ending alone does not tell you how a word is formed. At the other end, R leads with 12 matches, followed by F with 9 and B with 8.

Collins contains 78 of these words, NWL2023 has 62, and ENABLE has 55; the totals overlap. Although 64 entries have definitions, this pattern still includes plenty of obscure vocabulary. Check your game's word list before using an unfamiliar match.

Which matching words score highest?

QUOOKE earns the highest score at 19 points. JUDOKA, HUZOOR, ZUFOLI, and ZUFOLO each reach 18, putting uncommon words ahead of familiar options such as RUMORS and HUMOUR.

JUDOKA stands out as a more recognizable 18-point play, while CUTOFF scores 14. For a quick scan of the pattern, test likely R openings and S endings first: those positions account for 12 and 33 matches respectively.