6-letter words with A as the 2nd letter and O as the 4th letter

That pattern fixes the middle as _A_O__, leaving the first, third, fifth, and sixth letters open. Common examples include famous, labour, favour, layout, and parody; the endings vary sharply, though, with S dominating. Dictionary totals also differ: Collins includes more matches than NWL2023 or ENABLE, so check the word list used by your game before relying on an unfamiliar entry.

The pattern at a glance

• Exactly 221 matches place A second and O fourth in a six-letter word.
• Only 19 matches rank among common English words, so many entries are specialist vocabulary.
• An S ending leads with 105 words; E comes next with 21.
• PAJOCK scores 21 points, the highest raw word score in the group.

Which endings are most common?

An S ending is the standout: 105 of the 221 matches finish that way, while the next ending, E, appears on 21. That makes the S ending especially prominent in this pattern. A, D, and Y endings form much smaller groups, with 11, 9, and 9 words respectively.

Starting letters spread out more evenly than endings. C leads with 28 matches, followed by S at 23 and P at 22; B, G, and M each contribute 16. When the fixed slots leave choices elsewhere, try C first, then test the S and P starts.

The matching five-letter pattern has 121 entries; the seven-letter version has 253. This six-letter set sits between them, with 100 more than the shorter group and 32 fewer than the longer one.

6-letter words with A as the 2nd letter and O as the 4th letter

The words range from familiar terms such as FAMOUS, LABOUR, FAVOUR, and LAYOUT to less common forms such as KAZOOS and PAROLE. The 19 common entries are a small slice of the 221 total, so a recognizable word is not guaranteed.

For a high-value play, PAJOCK leads at 21 points; KAZOOS and JAMOKE score 19, while PAYOFF reaches 17. These are raw tile scores before board bonuses, and the top-scoring choices are less familiar than FAMOUS or LAYOUT. The fixed A and O leave four open slots, so test alternate letters there before settling on a play.