6-letter words with U as the 1st letter and I as the 4th letter

Lock in U at the start and I in the fourth spot, and the pattern becomes U _ _ I _ _. The 100 matches range from everyday words such as UPSIDE and UNWIND to less familiar entries. Only 6 fall among the most common English words, so the full set is broader than an ordinary vocabulary list.

At a glance: the U _ _ I _ _ pattern

• There are 100 tournament-dictionary words with U first and I fourth.
• UNLIKE, UPSIDE, URGING, and UPHILL are recognizable examples.
• The most frequent final letters are E, with 23 words, and S, with 21.
• UNZIPS and UPSIZE tie for the top score at 17 points.

Which endings appear most often?

E and S dominate the last position: 23 matches end in E, while 21 end in S. D follows with 12, then T with 10. When the first four letters are fixed, testing E or S in the final slot gives you the broadest starting branches.

The examples show several useful word families. UNLIKE and UNWISE share the UN- opening, while UPLIFT and UPLINK begin with UPL-. Others shift sharply in meaning: UMPIRE, UPTIME, and UPTICK all fit the same letter positions despite having different endings.

How do these 6-letter words score?

UNZIPS and UPSIZE lead the scores at 17 points each. UNFIXT scores 16, while UNMIXT and ULZIES score 15. The high scorers are not necessarily the words you will reach for first; UNLIKE and UPSIDE are more familiar choices, but do not top the scoring table.

The dictionary split is uneven: Collins includes 99 matches, NWL2023 includes 63, and ENABLE includes 59. Those collections overlap, so their counts should not be added together.