6-letter words with T as the 1st letter and S as the 4th letter

The fixed pattern is T _ _ S _ _: T starts every answer, and S sits in the fourth position. Familiar choices include TISSUE, THESIS, TRUSTS, and TOSSED, but only 8 of the 88 matches rank among the top 25,000 English words by frequency. Expect a mix of everyday vocabulary and less familiar game entries rather than a list of equally common choices.

At a glance: 88 matches and a clear end-letter leader

• There are 88 six-letter words matching T _ _ S _ _ across the tournament dictionaries.
• The most frequent final letter is S: 30 words end there, including TRUSTS and TWISTS.
• Another 12 words end in R, while 11 finish in L.
• Collins includes 86 matches; NWL2023 includes 64, and ENABLE includes 59.
• TISSUE and THESIS are familiar examples; TRASHY and TWISTY lead the score list at 12 points.

Which letters commonly finish these words?

S is the strongest ending by a wide margin: 30 matches finish with S, compared with 12 ending in R and 11 in L. TRUSTS, TWISTS, and TOSSES show how naturally this pattern accommodates plural forms, while TISSUE and THESIS finish differently.

The remaining endings are less frequent: D and Y each appear 8 times, E and N each appear 6 times, and H appears 3 times. That makes the final tile a useful constraint after you have placed T and the fourth-position S. TENSES and TENSED illustrate how a single final-letter change can point to related forms.

Which matching words score the most?

TRASHY, TWISTY, and THUSLY top the scores at 12 points each; THESPS and TAISCH follow at 11. For 6-letter words with T as the 1st letter and S as the 4th letter, the strongest scores come from less familiar spellings, not the everyday options.

TISSUE, THESIS, and TRUSTS are easier to recognize, but they score 7, 9, and 9 points respectively. The average score is 7.3, so a 12-point word stands out without being typical. Dictionary coverage also varies: check your game's word list before playing less familiar entries.