6-letter words with S as the 2nd letter and E as the 5th letter

The pattern fixes S in slot two and E in slot five, leaving four positions open. Collins accepts all 31 matches; ENABLE and NWL2023 each include 22. Just five are common by frequency, so familiar anchors such as ASLEEP and ISSUES stand out from a largely specialist pool. Check your game's word list before relying on a less familiar entry.

The pattern at a glance

• There are 31 six-letter matches with S second and E fifth.
• ENABLE and NWL2023 each include 22 matches; Collins includes all 31.
• Only 5 matches rank among the 25,000 most common English words.
• The final letter is S for 11 matches and R for 8.
• ASHKEY scores 16 points, the highest raw tile score in the group.

Which 6-letter words with S second and E fifth are familiar?

ASLEEP, ISSUES, ISSUED, and ESTEEM are recognizable starting points. The list has 26 defined entries, but only 5 meet the common-word frequency cutoff, so don't expect every valid match to be everyday vocabulary.

The first letter narrows the choices sharply: 8 matches begin with I, 7 with E, and 6 each with A or U. O and T account for 2 matches apiece. If you're working from a partial pattern, testing I first covers the largest single starting-letter group; A and U are tied just behind it.

Endings offer another useful split. S closes 11 words, R closes 8, and D closes 3. ISSUES ends in S, ISSUER in R, and ISSUED in D, making those familiar forms quick checks against the final tile.

Which matches score well in Scrabble?

ASHKEY leads the raw tile scores at 16 points, followed by USQUES at 15 and ESCHEW at 14. ISOLEX scores 13, while OSPREY scores 11. These less familiar entries can beat a common word on tile value, but a high rack score does not guarantee a legal play in your game's dictionary.

For a more familiar option, ISSUES, ISSUED, and ISSUER share the opening ISSU- and differ at the end. The pattern's 11 S-ending and 8 R-ending matches make those two final letters especially worth checking. Compare the neighboring patterns if the fifth tile turns out not to be E.