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7-letter words with Z as the 1st letter and O as the 4th letter

17 seven-letter words put Z first and O fourth, from familiar zeroing to specialist terms such as zymotic and zymomes.

17 wordsTop pick ZEROINGHighest score ZYMOTIC 23

With Z in 1st place, A is the most common 4th letter (18 words). The bar under each letter shows the size of its list.

  • Length
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Best words to play first 17 · most-used first

  • ZEROING17
  • ZYGOTES20
  • ZYGOTIC22
  • ZYMOGEN22
  • ZYMOSAN21
  • ZYMOSIS21
  • ZAMOUSE18
  • ZEDOARY20
  • ZEDONKS21
  • ZIMOCCA22
  • ZIPOLAS18
  • ZYGOMAS22
  • ZYGOSES20
  • ZYGOSIS20
  • ZYMOMES23
  • ZYMOSES21
  • ZYMOTIC23
All valid words 17

A to Z. Includes rare and Collins-only words. Linked tiles open the word's meaning, score and rhymes.

  • ZAMOUSE18
  • ZEDOARY20
  • ZEDONKS21
  • ZEROING17
  • ZIMOCCA22
  • ZIPOLAS18
  • ZYGOMAS22
  • ZYGOSES20
  • ZYGOSIS20
  • ZYGOTES20
  • ZYGOTIC22
  • ZYMOGEN22
  • ZYMOMES23
  • ZYMOSAN21
  • ZYMOSES21
  • ZYMOSIS21
  • ZYMOTIC23
Letters by positionIn 65% of these words the 2nd letter is Y.
2nd letter
  1. Y65%
  2. E18%
  3. I12%
3rd letter
  1. M47%
  2. G29%
  3. D12%
5th letter
  1. S29%
  2. T18%
  3. M12%
6th letter
  1. E29%
  2. I24%
  3. A18%
7th letter
  1. S53%
  2. C12%
  3. N12%

Highest-scoring words

Scrabble and Words With Friends points, before board bonuses
WordScrabbleWords With FriendsDictionaries
ZYMOTIC2324All three
ZYMOMES2324Collins only
ZYGOTIC2223All three
ZYMOGEN2224All three
ZYGOMAS2223All three
ZIMOCCA2225Collins only
ZYMOSAN2122All three
ZYMOSIS2121All three
ZYMOSES2121All three
ZEDONKS2122NWL only
ZYGOTES2020All three
ZEDOARY2019All three

The pattern is Z _ _ O _ _ _: keep Z fixed at the start and O in the fourth position. Only 17 words meet both clues, and none fall among the commonest English words, making this a narrow puzzle list rather than a set of everyday guesses. The dictionary totals also differ: Collins includes 15 matches, NWL2023 has 14, and ENABLE has 12.

At a glance: the Z___O__ pattern

  • There are 17 tournament-dictionary words matching Z _ _ O _ _ _.
  • Zeroing is the most familiar-looking example in this uncommon group.
  • Zymotic and zymomes lead the Scrabble scores at 23 points each.
  • Nine of the 17 words end in S.
  • No matching entry appears among the common-word group.

How unusual is Z in the first position and O in the fourth?

This combination has 17 matches, fewer than the Z-and-A, Z-and-G, or Z-and-T patterns in the fourth position, each of which has 18. The difference is small, but it shows how tightly the fourth-letter clue narrows an already unusual starting letter.

Compare the dictionary coverage before playing: 15 entries appear in Collins, 14 in NWL2023, and 12 in ENABLE. The overall count includes words present in at least one of those tournament lists, so a match is not guaranteed to work in every game.

  • The Z-and-O pattern has 17 matches.
  • Z-and-A, Z-and-G, and Z-and-T each have 18.
  • Collins includes 15 matches; ENABLE includes 12.

7-letter words with Z first and O fourth: scores and endings

Zymotic and zymomes each score 23 points in Scrabble, while zygotic, zymogen, zygomas, and zimocca score 22. These are strong raw-letter totals, but the top scorers are specialist vocabulary, not words most players will recognize at a glance.

The endings offer a more practical sorting clue: nine words finish with S, while C and N each account for two. Zeroing stands out as the accessible example; several others, including zymoses and zygoses, are much less familiar. Check your game's word list before committing to an obscure entry, because the dictionaries do not share every word.

  • Zymotic scores 23 points in Scrabble.
  • Zymomes also scores 23 points.
  • Nine of the 17 matches end in S.

Questions people ask

How many seven-letter words have Z first and O fourth?
There are 17 matching words in the combined tournament-dictionary count. The pattern is Z _ _ O _ _ _, and the total includes entries found in at least one of Collins, NWL2023, or ENABLE.
Which Z-and-O word scores the most in Scrabble?
Zymotic and zymomes tie for the highest score at 23 points each. Zygotic, zymogen, zygomas, and zimocca follow at 22 points, so the less familiar words carry the strongest raw scores.
Do all 17 words appear in every tournament dictionary?
No. Collins has 15 matches, NWL2023 has 14, and ENABLE has 12; the combined total counts a word if it appears in at least one list. Check the dictionary used by your game before playing an unfamiliar entry.

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