7-letter words with S as the 2nd letter and O as the 3rd letter

7-letter words with S as the 2nd letter and O as the 3rd letter number 48, led by familiar forms such as ISOLATE and ISOTOPE.

48 wordsTop pick ISOLATEHighest score ISOZYME 21

2 of 48 are everyday words (4%). Mostly rare words: great for Scrabble, tough for daily puzzles.

With S in 2nd place, T is the most common 3rd letter (61 words). The bar under each letter shows the size of its list.

  • Length
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
  • 11
  • 12
  • 13
  • 14
  • 15

Best words to play first 48 · most-used first

  • ISOLATE7
  • ISOTOPE9
  • ISOMERS9
  • ISOFORM12
  • ASOCIAL9
  • ISOTYPE12
  • ISOPODS10
  • ISOBARS9
  • ISOSPIN9
  • ISOZYME21
  • ISOAMYL12
  • ISOTOPY12
  • ISOETES7
  • TSOTSIS7
  • ISONOMY12
  • ISOTRON7
  • ISOLINE7
  • ESOTERY10
  • ISOBARE9
  • ISOBASE9
  • ISOBATH12
  • ISOCHOR12
  • ISODICA10
  • ISODOMA10
  • ISODONT8
  • ISODOSE8
  • ISOGAMY13
  • ISOGENY11
  • ISOGONE8
  • ISOGONS8
  • ISOGONY11
  • ISOGRAM10
  • ISOGRIV11
  • ISOHELS10
  • ISOHYET13
  • ISOKONT11
  • ISOLEAD8
  • ISOLOGS8
  • ISOMERE9
  • ISONOME9
  • ISOPACH14
  • ISOTACH12
  • ISOTONE7
  • PSOASES9
  • PSOATIC11
  • PSOCIDS12
  • TSOORIS7
  • TSOURIS7
All valid words 48

A to Z. Includes rare and Collins-only words. Linked tiles open the word's meaning, score and rhymes.

  • ASOCIAL9
  • ESOTERY10
  • ISOAMYL12
  • ISOBARE9
  • ISOBARS9
  • ISOBASE9
  • ISOBATH12
  • ISOCHOR12
  • ISODICA10
  • ISODOMA10
  • ISODONT8
  • ISODOSE8
  • ISOETES7
  • ISOFORM12
  • ISOGAMY13
  • ISOGENY11
  • ISOGONE8
  • ISOGONS8
  • ISOGONY11
  • ISOGRAM10
  • ISOGRIV11
  • ISOHELS10
  • ISOHYET13
  • ISOKONT11
  • ISOLATE7
  • ISOLEAD8
  • ISOLINE7
  • ISOLOGS8
  • ISOMERE9
  • ISOMERS9
  • ISONOME9
  • ISONOMY12
  • ISOPACH14
  • ISOPODS10
  • ISOSPIN9
  • ISOTACH12
  • ISOTONE7
  • ISOTOPE9
  • ISOTOPY12
  • ISOTRON7
  • ISOTYPE12
  • ISOZYME21
  • PSOASES9
  • PSOATIC11
  • PSOCIDS12
  • TSOORIS7
  • TSOTSIS7
  • TSOURIS7
Letters by positionIn 83% of these words the 1st letter is I.
1st letter
  1. I83%
  2. P6%
  3. T6%
4th letter
  1. T17%
  2. G15%
  3. B8%
5th letter
  1. O31%
  2. A17%
  3. E13%
6th letter
  1. N17%
  2. R13%
  3. I13%
7th letter
  1. E25%
  2. S25%
  3. Y13%

Highest-scoring words

Scrabble and Words With Friends points, before board bonuses
Score spreadMost of these words score 9 in Scrabble; ISOZYME tops the list with 21. Scores before board bonuses.
  1. 77 points: 8 words
  2. 8 points: 6 words
  3. 99 points: 10 words
  4. 10 points: 6 words
  5. 1111 points: 5 words
  6. 12 points: 9 words
  7. 1313 points: 2 words
  8. 14 points: 1 words
  9. 1515 points: 0 words
  10. 16 points: 0 words
  11. 1717 points: 0 words
  12. 18 points: 0 words
  13. 1919 points: 0 words
  14. 20 points: 0 words
  15. 2121 points: 1 words
WordScrabbleWords With FriendsDictionaries
ISOZYME2121All three
ISOPACH1415All three
ISOGAMY1314All three
ISOHYET1311All three
ISOFORM1213Collins · NWL
ISOTYPE1212All three
ISOAMYL1213Collins only
ISOTOPY1212All three
ISONOMY1213All three
ISOBATH1212All three
ISOCHOR1212All three
ISOTACH1212All three

The pattern fixes the middle as “so,” but most matches begin with I: 40 of the 48 start with that letter. ISOLATE and ISOTOPE are among the more recognizable choices; many other entries are specialist terms. The total follows Collins, while NWL2023 and ENABLE accept smaller sets, so your game’s dictionary can change which candidates work.

At a glance: 7-letter words with S second and O third

  • There are 48 matches across Collins, the largest dictionary set for this pattern.
  • NWL2023 includes 36 matches, while ENABLE includes 33.
  • Forty words begin with I; P and T account for three each.
  • The most frequent final letters are E and S, with 12 words apiece.
  • Only two entries rank among the 25,000 most common English words.

Which words fit the S-O pattern?

ISOLATE and ISOTOPE show the familiar “iso-” opening, and ISOMERS, ISOFORM, and ISOTYPE follow the same shape. These examples make the pattern easier to scan: after the first letter, the next two positions are fixed, while the remaining four letters vary.

The opening is unusually concentrated. I supplies 40 matches, while the other eight are split among P, T, A, and E. For comparison, the neighboring pattern with R in position two has 502 seven-letter matches, far more than this S-and-O combination, while E and S tie as the most common endings with 12 matches each.

Which matching word scores the most?

Note

The 48-word total is Collins-based; NWL2023 has 36 and ENABLE has 33. Check your game’s word list before relying on a less familiar entry such as ISOZYME.

Questions people ask

How many 7-letter words have S second and O third?
There are 48 seven-letter matches in Collins. The count is smaller in other tournament lists: NWL2023 has 36, and ENABLE has 33. ISOLATE and ISOTOPE are two recognizable examples that fit the fixed second- and third-letter positions.
What is the highest-scoring word with S second and O third?
ISOZYME scores 21 points, the highest score among these matches. ISOPACH follows at 14, while ISOGAMY and ISOHYET each score 13. ISOZYME is less familiar than ISOLATE, but its score makes it the standout entry.
Do most seven-letter S-O words start with I?
Yes. Forty of the 48 matches begin with I, including ISOMERS, ISOFORM, and ISOTYPE. The remaining words start with P, T, A, or E, so an I at the beginning is a strong pattern clue, though not a guarantee.

Keep going