7-letter words with I as the 2nd letter and S as the 6th letter

The pattern is _I___S_: keep I in slot two and S in slot six, then use the remaining five positions to narrow a rack or solve a crossword. Familiar matches include DISEASE, BIGGEST, HIGHEST, WITNESS, and LICENSE. The set spans 187 tournament-dictionary entries, but only 18 rank among the top 25,000 English words by frequency, so many matches are specialist vocabulary.

Quick facts about this letter pattern

• 187 entries fit the fixed pattern in at least one tournament dictionary.
• 183 appear in Collins, compared with 145 in NWL2023 and 130 in ENABLE.
• DISEASE, BIGGEST, HIGHEST, and WITNESS are recognizable matches.
• PIXYISH tops the score list at 22 points; HICKISH, JIGGISH, and MINXISH each score 19.
• Just 18 entries meet the common group.

How many 7-letter words have I second and S sixth?

There are 187 matches. Compared with nearby second-letter patterns, I sits just above U at 184, while A has 317, O has 248, and E has 214. That makes I a tighter filter than those three vowels, though it still beats N at 92 and R at 87.

The final letter is often T: 72 matches end that way, while E and S each finish 36 and H finishes 31. DISEASE and WITNESS show how the fixed S can sit near a word's end; BIGGEST and HIGHEST are familiar T-ending examples.

Which matches offer the strongest scores?

Unusual letter combinations lead the scoring list. PIXYISH tops it at 22 points; HICKISH, JIGGISH, and MINXISH each reach 19, while ZIPLESS and SIZEISM score 18. Those are strong rack candidates when the letters fit, but DISEASE and LICENSE are easier to recognize and recall.

For a seven-tile rack, lock I and S into their known positions first, then test possible first and final letters. The T-ending group is the largest, with 72 matches, so check T before less common endings.

One limitation: only 18 matches meet the common group, and 129 have a definition in the underlying word data. Collins includes 183 matches, NWL2023 has 145, and ENABLE has 130, so tournament acceptance varies by dictionary. Check your game's word list before committing an unfamiliar form.