6-letter words with Y as the 2nd letter and O as the 3rd letter

The pattern is _YO___, but the matches cluster around a few recognizable forms rather than everyday vocabulary. Nine begin with M, including MYOPIC, MYOPIA, MYOSIN, and MYOMAS; eight end in S. GYOZAS stands apart as the strongest scorer, while the dictionary counts vary: Collins accepts all 16, compared with 13 in NWL2023 and 12 in ENABLE.

At a glance: a compact, MYO-heavy pattern

• There are 16 six-letter matches for the fixed Y-O positions.
• Nine words start with M; three start with P, and four start with G, H, K, or R.
• Eight entries end in S, making that the most common final letter.
• GYOZAS scores 19 points, ahead of MYOPIC at 15.
• None of the matches falls among the top 25,000 English words by frequency.

How many 6-letter words have Y second and O third?

There are 16 matches, and the strongest recognition clue is the MYO- cluster. MYOPIC and MYOPIA share a familiar opening, while MYOSIN and MYOSIS add another related-looking pair. MYOMAS, MYOPES, MYOTIC, and MYOGEN round out the M-heavy group.

The less common openings make the pattern broader than a single word family: GYOZAS, HYOIDS, KYOGEN, and RYOKAN each start differently. Three entries begin with P: PYONER, PYoses, and PYOSIS. This mix matters when crossing letters are uncertain; checking only the M words misses seven matches.

How do these six-letter words score?

GYOZAS leads the Scrabble scores at 19, with MYOPIC next at 15 and KYOGEN at 14. GYOZAS is the standout rack play because its Z carries a high tile value; save it for a premium square when the board allows. MYOPIC offers a more familiar alternative with a solid 15-point base score.

Vocabulary is the main limitation: all 16 are outside the common-word group, so a pattern match may still feel unfamiliar. Dictionary coverage also differs, with Collins listing 16, NWL2023 13, and ENABLE 12. For tournament play, check the word list used by your game before committing an obscure entry.