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6-letter words with S as the 2nd letter and L as the 4th letter

6-letter words with S as the 2nd letter and L as the 4th letter number 10, from familiar ASYLUM to high-scoring ISOLEX.

10 wordsTop pick ASYLUMHighest score ISOLEX 13

2 of 10 are everyday words (20%). A mix of familiar words and game-only finds.

  • 4th letter
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

With S in 2nd place, E is the most common 4th letter (33 words). The bar under each letter shows the size of its list.

  • Length
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
  • 11
  • 12
  • 13
  • 14
  • 15

Best words to play first 10 · most-used first

  • ASYLUM11
  • PSALMS10
  • ASHLAR9
  • OSTLER6
  • PSYLLA11
  • ISTLES6
  • ASHLER9
  • ESILES6
  • ISOLEX13
  • ISOLOG7
All valid words 10

A to Z. Includes rare and Collins-only words. Linked tiles open the word's meaning, score and rhymes.

  • ASHLAR9
  • ASHLER9
  • ASYLUM11
  • ESILES6
  • ISOLEX13
  • ISOLOG7
  • ISTLES6
  • OSTLER6
  • PSALMS10
  • PSYLLA11

Highest-scoring words

Scrabble and Words With Friends points, before board bonuses
WordScrabbleWords With FriendsDictionaries
ISOLEX1314Collins only
ASYLUM1113All three
PSYLLA1113All three
PSALMS1013All three
ASHLAR99All three
ASHLER99All three
ISOLOG79All three
OSTLER67All three
ISTLES67All three
ESILES67Collins only

The pattern is tight: just 10 words match, and only two rank among the commonest English entries. ASYLUM is the recognizable standout; the other choices range from PSALMS and ASHLAR to less familiar forms such as ISOLEX. Collins accepts all 10, while ENABLE and NWL2023 each accept eight.

At a glance: the S-L pattern

  • Exactly 10 tournament-dictionary words place S second and L fourth.
  • Only two matches are common; the other eight are less familiar.
  • Initial A and I tie at three words apiece; P begins two.
  • ISOLEX leads the score list at 13, ahead of ASYLUM and PSYLLA at 11.

6-letter words with S as the 2nd letter and L as the 4th letter

The first letter is not predictable from the fixed S-L frame. A and I each start three entries, P starts two, and E and O contribute one apiece. A known opening letter can cut the candidates quickly: A points to ASYLUM, while P leaves PSALMS or PSYLLA. With I, compare ISOLEX, ISOLOG, and ISTLES.

Endings are similarly concentrated: R and S each finish three words, while A, G, M, and X finish one each. ASYLUM ends in M; PSALMS ends in S; ASHLAR and OSTLER end in R. Use the final tile with the first letter to narrow your options, rather than treating the middle pattern as enough.

How should you choose a scoring play?

ISOLEX scores 13, the top raw score in this group, but a premium square changes the board result; compare letter values before choosing it. ASYLUM and PSYLLA each score 11, and PSALMS scores 10. No entry reaches 14 points, so this is not a cluster of premium-letter scorers.

The average base score is 8.8, below ISOLEX's 13-point peak, so the top scorer is not representative of the set. Inspect the board for a letter bonus or a scoring lane; the raw total alone does not make ISOLEX the best move. The two common entries are more recognizable, but they do not lead on score.

  • Play ASYLUM when the A opening fits; its 11-point base score beats ASHLAR's 9.
  • Choose ISOLEX for the highest listed base score, not because it is one of the two common matches.
  • Check your game's word list: Collins includes two more matches than ENABLE or NWL2023.

Questions people ask

How many six-letter words have S second and L fourth?
There are 10 matches across the tournament dictionaries. Collins lists all 10, while ENABLE and NWL2023 each list eight. The pattern gives you a small candidate set, but two entries are common and the rest are less familiar.
Which S-second, L-fourth word scores the most?
ISOLEX has the highest listed base score at 13 points. ASYLUM and PSYLLA follow at 11 points each, while PSALMS scores 10. Board placement and premium squares can change the value of a play.
What letters can come first in this six-letter pattern?
A and I each begin three matches, P begins two, and E and O begin one apiece. That makes an opening A or I more common in this set, with ASYLUM and ISOLEX among the recognizable examples.

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