6-letter words with O as the 1st letter and P as the 2nd letter

The O-P opening brings together everyday words such as OPTION, OPENED, OPENLY and OPENER, plus specialist entries including OPCODE and OPHITE. Collins lists all 27 matches; ENABLE and NWL2023 each list 21. Ten rank among the top 25,000 English words by frequency, so this pattern mixes familiar vocabulary with words more likely to appear in tournament play.

At a glance: the O-P opening

• Collins lists 27 matches; ENABLE and NWL2023 each list 21.
• Ten are common by frequency, including OPTION, OPENED and OPENLY.
• OPAQUE tops the scoring list at 17 Scrabble points.
• Nine entries end in S, more than any other final letter here.

Which endings occur most often?

S is the standout ending: 9 of these words finish with it, compared with 6 ending in E and 4 ending in D. Examples in the S group include OPTICS, OPERAS, OPINES, OPUS​ES and OPIUMS. That cluster gives you several ways to use a known final S without changing the first two letters.

The smaller ending groups still offer recognizable choices. OPENED and OPINED finish in D, while OPTION and OPENER finish in N and R respectively. When a puzzle fixes O and P at the start, checking likely endings can narrow the choices faster than scanning every remaining letter combination.

6-letter words with O as the 1st letter and P as the 2nd letter

OPAQUE is the scoring standout at 17 points. OPENLY, OPCODE, OPPUGN and OPHITE each score 11, while OPPOSE and OPTICS score 10. OPAQUE’s Q does the heavy lifting; the practical lesson is to look for a premium square that boosts the Q rather than settling for a routine placement.

Dictionary coverage is not identical across games: the group has 27 Collins entries but 21 in each of ENABLE and NWL2023. Treat unusual options such as OPPUGN and OPHITE as worth checking before you play; familiarity alone does not guarantee acceptance. For everyday use, OPTION and OPENED are safer words to try first.