6-letter words with M as the 5th letter and E as the 6th letter

The ME ending is fixed, so the first four letters carry the whole search. Common picks such as BECOME, BECAME, and VOLUME sit alongside rarer plays like ZYMOME and SQUAME. Fourteen of the 69 matches fall among the most familiar English words, and the rest test how well you know tournament vocabulary.

The ME pattern at a glance

• All 69 matches end in ME, with M locked into the fifth slot.
• Fourteen entries count as common English words; BECOME, BECAME, and INCOME lead that group.
• S starts eight matches, and A, B, and R start seven each.
• ZYMOME tops the score list at 22 points, ahead of ENZYME at 20.
• Word-list coverage runs 68 for Collins, 47 for NWL2023, and 45 for ENABLE.

Which first letters lead the ME words?

S is the most productive opening with eight matches, but the next three letters sit close behind: A, B, and R each start seven. That flat spread means the first tile rarely pins down a single answer, unlike patterns where one letter dominates.

Familiar A and B examples include ASSUME, AFLAME, BECOME, and BECAME, while R gives REGIME, RESUME, RENAME, and RACEME.

How high do the letter values push these words?

ZYMOME leads at 22 points thanks to its Z, followed by ENZYME at 20 and EXHUME at 18. SQUAME reaches 17, and WAKAME, LEXEME, and TAXEME each score 15.

The gap between ZYMOME and the everyday BECOME is wide, so a rare spelling can be worth hunting when the board has room. Only 50 of the 69 matches carry a dictionary definition, and acceptance changes with Collins, NWL2023, and ENABLE. Check your game's word list before committing an uncommon entry.

How does this ME group compare with its neighbours?

At 69 matches, the ME group sits well below the busiest fifth-position sets: 6-letter words with L fifth and E last number 501, and the I-E set holds 392. Even S fifth and E last, at 189 words, is more than twice this list, so the ME pattern is one of the smaller families.