6-letter words with M as the 1st letter and E as the 2nd letter

The fixed ME opening gives you a focused pattern rather than a general list of six-letter words. Familiar entries include MEMBER, MENTAL, MEMORY, METHOD, and MEDIUM, but only 34 matches are common by frequency. That gap matters in a puzzle: knowing the pattern can surface possibilities, while many valid entries remain rare.

6-letter words starting ME at a glance

• The pattern has 193 tournament-dictionary matches.
• Only 34 matches fall among the top 25,000 English words by frequency.
• MEMBER, MENTAL, MEMORY, METHOD, and MEDIUM are familiar examples.
• Final S is the most frequent ending, appearing in 50 words.
• MEZZOS, MEZUZA, and MEZZES each score 26 in the scoring data.

Which ME words score the most?

MEZZOS, MEZUZA, and MEZZES tie for the top score at 26. Their Z tiles do the heavy lifting, so these are score-first plays rather than everyday vocabulary picks.

MEZCAL follows at 19, while MEAZEL and MEZAIL score 17 each. Those less familiar options show why checking your rack against the whole pattern can matter more than guessing from common words alone.

For more recognizable options, MEEKLY scores 15; MEDFLY and MEJLIS also reach 15. Treat these scores as a shortlist, then confirm the word in your game's dictionary.

How do these six-letter ME words end?

Final S leads with 50 matches, followed by D with 26. MEMBER, METALS, and MERITS show the range of S-ending forms; MEDALS and MELTED illustrate the D group. MEDALS and MELTED show the final-D branch, while METALS and MERITS illustrate common S endings.

The remaining leading endings are E with 22 and R with 20. Those counts make the last tile a useful filter when your pattern already fixes M and E at the start. Counts combine words accepted by at least one of ENABLE, Collins, and NWL2023, so a particular game's dictionary may differ.