6-letter words with E as the 2nd letter and U as the 4th letter

This pattern has an unusual mix: familiar words such as RETURN and RESULT sit beside a top scorer most players rarely reach for. R starts 42 matches, while D starts 24 and B starts 20. The final letter is often E or S, which matters when you solve a clue or test whether a candidate fits your game.

Words, endings, and scores at a glance

• RETURN and RESULT are recognizable matches with R in the first position.
• BEAUTY, SECURE, DEPUTY, and REFUSE also fit the fixed E and U positions.
• R begins 42 matches; D begins 24, and B begins 20.
• E is the most frequent final letter at 43 matches; S follows at 36.
• MEZUZA tops the score list with 26 points.

6-letter words with E as the 2nd letter and U as the 4th letter

There are 149 matches. For comparison, the pattern with E second and I fourth has 383 six-letter words, so fixing U in the fourth spot cuts the options considerably. Among the matches, 22 are classed as common, while 123 have definitions.

The endings narrow the search further: 43 words finish in E and 36 finish in S. Try candidates such as SECURE, REFUSE, and RESUME when the final tile is still unknown; a final E or S accounts for more than half of the matches. The remaining endings are much less frequent.

Which matches score well, and which lists include them?

MEZUZA scores 26 points, far ahead of familiar options such as SEQUEL, SEQUIN, REQUIN, and REQUIT, each listed at 15. That gap comes from the high-value letters, not from a long word: check the board premium squares before committing a rare play.

Dictionary coverage is not uniform: Collins includes 148 matches, NWL2023 includes 116, and ENABLE includes 110. Treat the broad total as a starting point, not a guarantee that every candidate is accepted in your game. MEZUZA is the standout score, but everyday words such as RESULT and BEAUTY are easier to recognize.